PDBsum entry 8hxw

Hydrolase

PDB id: 8hxw

Contents

Protein chains

231 a.a.

Ligands

5ZR ×2

FMT ×2

Metals

_ZN ×4

Waters ×107

PDB id:

8hxw

Name:

Hydrolase

Title:

Crystal structure of b1 vim-2 mbl in complex with 2-amino-5- heptylthiazole-4-carboxylic acid

Structure:

Beta-lactamase class b vim-2. Chain: a, b. Synonym: blavim-2,metallo-beta-lactamase,metallo-beta-lactamase vim- 2,vim-2 beta-lactamase,vim-2 class b metallo b-lactamase,vim-2 metallo-beta-lactamase,vim-2 type metallo-beta-lactamase. Engineered: yes

Source:

Pseudomonas aeruginosa. Organism_taxid: 287. Gene: blavim-2, bla vim-2, bla-vim-2, blasvim-2, blavim2, vim-2, vim-2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Resolution:

2.39Å R-factor: 0.171 R-free: 0.250

Authors:

Y.-H.Yan,K.-R.Zhu,G.-B.Li

Key ref:

Y.H.Yan et al. (2023). Discovery of 2-Aminothiazole-4-Carboxylic acids as broad-Spectrum metallo-Beta-Lactamase inhibitors by mimicking carbapenem hydrolysate binding.. J.Med.Chem., 66, 13746. PubMed id: 37791640 DOI: 10.1021/ACS.JMEDCHEM.3C01189

Date:

05-Jan-23 Release date: 01-Nov-23

Protein chains

Q9K2N0  (Q9K2N0_PSEAI) -  Beta-lactamase class B VIM-2 from Pseudomonas aeruginosa

Seq: 266 a.a.

Struc: 231 a.a.