|
|
||
|
|
|
|
|
UniProt functional annotation for Q03181 | ||
|
|
|
|
|
|
||
| UniProt code: Q03181. |
|
||
| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
|
||
|
||
| Function: | |
Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma- linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand. {ECO:0000269|PubMed:1333051, ECO:0000269|PubMed:15604518}. |
|
||
| Subunit: | |
Heterodimer with the retinoid X receptor. Interacts (via domain NR LBD) with CRY1 and CRY2 in a ligand-dependent manner (By similarity). {ECO:0000250|UniProtKB:P35396, ECO:0000269|PubMed:10809235, ECO:0000269|PubMed:16405912, ECO:0000269|PubMed:16931011, ECO:0000269|PubMed:17560785, ECO:0000269|PubMed:19116277, ECO:0000269|PubMed:19464171}. |
| Subcellular location: | |
Nucleus. |
| Tissue specificity: | |
Ubiquitous with maximal levels in placenta and skeletal muscle. |
| Similarity: | |
Belongs to the nuclear hormone receptor family. NR1 subfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.