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UniProt functional annotation for Q13219 | ||
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| UniProt code: Q13219. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF. {ECO:0000269|PubMed:10077652, ECO:0000269|PubMed:10913121, ECO:0000269|PubMed:11522292}. |
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| Catalytic activity: | |
Reaction=Cleavage of the 135-Met-|-Lys-136 bond in insulin-like growth factor binding protein (IGFBP)-4, and the 143-Ser-|-Lys-144 bond in IGFBP-5.; EC=3.4.24.79; |
| Cofactor: | |
Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250}; Note=Binds 1 zinc ion per subunit. {ECO:0000250}; |
| Activity regulation: | |
Inhibited by complexation with the proform of PRG2. {ECO:0000269|PubMed:10913121}. |
| Subunit: | |
Homodimer; disulfide-linked. In pregnancy serum, predominantly found as a disulfide-linked 2:2 heterotetramer with the proform of PRG2. {ECO:0000269|PubMed:10913121, ECO:0000269|PubMed:12421832, ECO:0000269|PubMed:7685339}. |
| Subcellular location: | |
Secreted {ECO:0000269|PubMed:10077652}. |
| Tissue specificity: | |
High levels in placenta and pregnancy serum. In placenta, expressed in X cells in septa and anchoring villi, and in syncytiotrophoblasts in the chorionic villi. Lower levels are found in a variety of other tissues including kidney, myometrium, endometrium, ovaries, breast, prostate, bone marrow, colon, fibroblasts and osteoblasts. {ECO:0000269|PubMed:10077652, ECO:0000269|PubMed:10491647, ECO:0000269|PubMed:7508748, ECO:0000269|PubMed:7526035}. |
| Developmental stage: | |
Present in serum and placenta during pregnancy; levels increase throughout pregnancy. {ECO:0000269|PubMed:10491647, ECO:0000269|PubMed:7539791}. |
| Induction: | |
By 8-bromoadenosine-3',5'-phosphate. {ECO:0000269|PubMed:8620868}. |
| Ptm: | |
There appear to be no free sulfhydryl groups. |
| Similarity: | |
Belongs to the peptidase M43B family. {ECO:0000305}. |
| Sequence caution: | |
Sequence=AAC50543.1; Type=Frameshift; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.