UniProt functional annotation for P31639

UniProt code: P31639.

Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Function:		Sodium-dependent glucose transporter. Has a Na(+) to glucose coupling ratio of 1:1.
Function:		Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules.
Subcellular location:		Membrane; Multi-pass membrane protein.
Disease:		Renal glucosuria (GLYS) [MIM:233100]: A disorder characterized by persistent isolated glucosuria, normal fasting serum glucose concentration, decreased renal tubular resorption of glucose from the urine, and absence of any other signs of tubular dysfunction. {ECO:0000269|PubMed:14614622}. Note=The disease is caused by variants affecting the gene represented in this entry.
Similarity:		Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.