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UniProt functional annotation for P23975 | ||
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| UniProt code: P23975. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Amine transporter. Terminates the action of noradrenaline by its high affinity sodium-dependent reuptake into presynaptic terminals. {ECO:0000269|PubMed:2008212}. |
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| Subunit: | |
Interacts with PRKCABP. {ECO:0000269|PubMed:11343649}. |
| Subcellular location: | |
Cell membrane {ECO:0000269|PubMed:2008212}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q7K4Y6}. |
| Disease: | |
Orthostatic intolerance (OI) [MIM:604715]: Syndrome characterized by lightheadedness, fatigue, altered mentation and syncope. It is associated with postural tachycardia. Plasma norepinephrine concentration is abnormally high. {ECO:0000269|PubMed:10684912}. Note=The disease is caused by variants affecting the gene represented in this entry. |
| Miscellaneous: | |
This protein is the target of psychomotor stimulants such as amphetamines or cocaine. |
| Similarity: | |
Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A2 subfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.