PDBsum entry 8h0p

Membrane protein

PDB id: 8h0p

Contents

Protein chains

291 a.a.

213 a.a.

338 a.a.

231 a.a.

54 a.a.

Ligands

ASN-LEU-TRP-ALA-THR-GLY-HIS-PHE-MET-GLY

PDB id:

8h0p

Name:

Membrane protein

Title:

Structure of the nmb30-nmbr and gq complex

Structure:

Nmb30. Chain: l. Engineered: yes. Neuromedin-b receptor. Chain: r. Synonym: nmb-r,epididymis tissue protein li 185a,neuromedin-b- preferring bombesin receptor. Engineered: yes. Mutation: yes.

Source:

Synthetic: yes. Homo sapiens. Organism_taxid: 9606. Human. Gene: nmbr. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: gnb1. Mus musculus.

Authors:

C.Li,Y.Xu,H.Liu,H.Cai,H.E.Xu,W.Yin

Key ref:

C.Li et al. (2023). Molecular recognition of itch-Associated neuropeptide bombesin receptors. Cell res, 33, 184.

Date:

30-Sep-22 Release date: 09-Aug-23

Protein chain

P28336  (NMBR_HUMAN) -  Neuromedin-B receptor from Homo sapiens

Seq: 390 a.a.

Struc: 291 a.a.*

Protein chain

P63092  (GNAS2_HUMAN) -  Guanine nucleotide-binding protein G(s) subunit alpha isoforms short from Homo sapiens

Seq: 394 a.a.

Struc: 213 a.a.*

Protein chain

P63096  (GNAI1_HUMAN) -  Guanine nucleotide-binding protein G(i) subunit alpha-1 from Homo sapiens

Seq: 354 a.a.

Struc: 213 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 338 a.a.

Protein chain

No UniProt id for this chain

Struc: 231 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 54 a.a.

* PDB and UniProt seqs differ at 189 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????