UniProt functional annotation for P29016



	UniProt functional annotation for P29016

UniProt code: P29016.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells. {ECO:0000269|PubMed:10981968, ECO:0000269|PubMed:14716313}.

Subunit: Heterodimer with B2M (beta-2-microglobulin). Interacts with saposin C. {ECO:0000269|PubMed:14716313, ECO:0000269|PubMed:14764708, ECO:0000269|PubMed:16874306}.

Subcellular location: Cell membrane {ECO:0000269|PubMed:10899914, ECO:0000269|PubMed:10981968, ECO:0000269|PubMed:14716313}; Single-pass type I membrane protein {ECO:0000255}. Endosome membrane {ECO:0000269|PubMed:10899914, ECO:0000269|PubMed:14716313}; Single-pass type I membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:10899914, ECO:0000269|PubMed:10981968, ECO:0000269|PubMed:14716313}; Single-pass type I membrane protein {ECO:0000255}. Note=Subject to intracellular trafficking between the cell membrane, endosomes and lysosomes. {ECO:0000269|PubMed:10899914, ECO:0000269|PubMed:10981968, ECO:0000269|PubMed:14716313}.

Tissue specificity: Expressed on cortical thymocytes, on certain T-cell leukemias, and in various other tissues.

Miscellaneous: During protein synthesis and maturation, CD1 family members bind endogenous lipids that are replaced by lipid or glycolipid antigens when the proteins are internalized and pass through endosomes or lysosomes, before trafficking back to the cell surface. Interaction with saposin C is required for the loading of bacterial lipid antigens onto CD1B in the lysosome.

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells. {ECO:0000269\|PubMed:10981968, ECO:0000269\|PubMed:14716313}.


Subunit:		Heterodimer with B2M (beta-2-microglobulin). Interacts with saposin C. {ECO:0000269\|PubMed:14716313, ECO:0000269\|PubMed:14764708, ECO:0000269\|PubMed:16874306}.
Subcellular location:		Cell membrane {ECO:0000269\|PubMed:10899914, ECO:0000269\|PubMed:10981968, ECO:0000269\|PubMed:14716313}; Single-pass type I membrane protein {ECO:0000255}. Endosome membrane {ECO:0000269\|PubMed:10899914, ECO:0000269\|PubMed:14716313}; Single-pass type I membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269\|PubMed:10899914, ECO:0000269\|PubMed:10981968, ECO:0000269\|PubMed:14716313}; Single-pass type I membrane protein {ECO:0000255}. Note=Subject to intracellular trafficking between the cell membrane, endosomes and lysosomes. {ECO:0000269\|PubMed:10899914, ECO:0000269\|PubMed:10981968, ECO:0000269\|PubMed:14716313}.
Tissue specificity:		Expressed on cortical thymocytes, on certain T-cell leukemias, and in various other tissues.
Miscellaneous:		During protein synthesis and maturation, CD1 family members bind endogenous lipids that are replaced by lipid or glycolipid antigens when the proteins are internalized and pass through endosomes or lysosomes, before trafficking back to the cell surface. Interaction with saposin C is required for the loading of bacterial lipid antigens onto CD1B in the lysosome.