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UniProt functional annotation for P35408 | ||
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| UniProt code: P35408. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function. |
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| Subunit: | |
Interacts with FEM1A. {ECO:0000269|PubMed:16424369}. |
| Subcellular location: | |
Cell membrane; Multi-pass membrane protein. |
| Tissue specificity: | |
High in intestine and in peripheral blood mononuclear cells; low in lung, kidney, thymus, uterus, vasculature and brain. Not found in liver, heart, retina oe skeletal muscle. |
| Ptm: | |
Phosphorylation mediates agonist-mediated desensitization by promoting cytoplasmic retention. {ECO:0000269|PubMed:11597569, ECO:0000269|PubMed:14709160}. |
| Similarity: | |
Belongs to the G-protein coupled receptor 1 family. {ECO:0000255|PROSITE-ProRule:PRU00521}. |
Annotations taken from UniProtKB at the EBI.