PDBsum entry 8g94

Guanine nucleotide-binding protein

PDB id: 8g94

Contents

Protein chains

288 a.a.

221 a.a.

337 a.a.

58 a.a.

231 a.a.

25 a.a.

27 a.a.

PDB id:

8g94

Name:

Guanine nucleotide-binding protein

Title:

Structure of cd69-bound s1pr1 coupled to heterotrimeric gi

Structure:

Sphingosine 1-phosphate receptor 1. Chain: a. Synonym: s1p receptor 1,s1p1,endothelial differentiation g-protein coupled receptor 1,sphingosine 1-phosphate receptor edg-1,s1p receptor edg-1. Engineered: yes. Guanine nucleotide-binding protein g(i) subunit alpha-1. Chain: b. Synonym: adenylate cyclase-inhibiting g alpha protein.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: s1pr1, chedg1, edg1. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293s gnti. Expression_system_atcc_number: crl-3022. Gene: gnai1.

Authors:

H.Chen,X.Li

Key ref:

H.Chen et al. Transmembrane protein cd69 acts as an s1pr1 agonist. Elife, . PubMed id: 37039481

Date:

21-Feb-23 Release date: 19-Apr-23

Protein chain

P21453  (S1PR1_HUMAN) -  Sphingosine 1-phosphate receptor 1 from Homo sapiens

Seq: 382 a.a.

Struc: 288 a.a.

Protein chain

P63096  (GNAI1_HUMAN) -  Guanine nucleotide-binding protein G(i) subunit alpha-1 from Homo sapiens

Seq: 354 a.a.

Struc: 221 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 337 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 58 a.a.

Protein chain

No UniProt id for this chain

Struc: 231 a.a.

Protein chain

Q07108  (CD69_HUMAN) -  Early activation antigen CD69 from Homo sapiens

Seq: 199 a.a.

Struc: 25 a.a.

Protein chain

Q07108  (CD69_HUMAN) -  Early activation antigen CD69 from Homo sapiens

Seq: 199 a.a.

Struc: 27 a.a.

* PDB and UniProt seqs differ at 2 residue positions (black crosses)