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UniProt functional annotation for P42166 | ||
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| UniProt code: P42166. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
May be involved in the structural organization of the nucleus and in the post-mitotic nuclear assembly. Plays an important role, together with LMNA, in the nuclear anchorage of RB1. |
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| Function: | |
TP and TP5 may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide. |
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| Subunit: | |
Interacts with LMNA, BANF1 and RB1 and with chromosomes. Associates directly or indirectly with lamins at specific cell-cycle stages. Interacts with CMTM6 (PubMed:28813417). {ECO:0000269|PubMed:10984438, ECO:0000269|PubMed:12475961, ECO:0000269|PubMed:28813417, ECO:0000269|PubMed:9707448}. |
| Subcellular location: | |
Nucleus. Chromosome. Note=Expressed diffusely throughout the nucleus. |
| Tissue specificity: | |
Expressed in many tissues. Most abundant in adult thymus and fetal liver. |
| Domain: | |
The N-terminal part contains two structurally independent, non- interacting domains: LEM-like (also called LAP2-N or LEM-D) and LEM (also called LAP2-C or LEM-B). LEM-like binds DNA while LEM interacts with BANF1. |
| Domain: | |
The C-terminal domain forms a four-stranded coiled coil. {ECO:0000250}. |
| Ptm: | |
Phosphorylated in a mitose-specific manner. {ECO:0000269|PubMed:9707448}. |
| Pharmaceutical: | |
TP5 is available under the names Timunox (Cilag), Sintomodulina (Italofarmaco) and Mepentil (Recordati). Used in primary and secondary immune deficiencies, autoimmunity, infections and cancer. |
| Similarity: | |
Belongs to the LEM family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.