PDBsum entry 8f7s

Signaling protein

PDB id: 8f7s

Contents

Protein chains

289 a.a.

221 a.a.

338 a.a.

57 a.a.

19 a.a.

Ligands

TYR-DAL-PHE-GLU-VAL-VAL-GLY-NH2 ×2

CLR ×5

PLM ×12

PDB id:

8f7s

Name:

Signaling protein

Title:

Gi bound delta-opioid receptor in complex with deltorphin

Structure:

Delta-type opioid receptor. Chain: r, d. Synonym: d-or-1,dor-1. Engineered: yes. Deltorphin. Chain: p, q. Fragment: unp residues 107-113. Synonym: [d-ala2]-deltorphin ii. Engineered: yes.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: oprd1, oprd. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Synthetic: yes. Phyllomedusa. Leaf frogs.

Authors:

Y.Wang,Y.Zhuang,J.F.Diberto,X.E.Zhou,G.P.Schmitz,Q.Yuan,M.K.Jain, W.Liu,K.Melcher,Y.Jiang,B.L.Roth,H.E.Xu

Key ref:

Y.Wang et al. (2023). Structures of the entire human opioid receptor family. Cell, 186, 413. PubMed id: 36638794

Date:

20-Nov-22 Release date: 14-Dec-22

Protein chains

P41143  (OPRD_HUMAN) -  Delta-type opioid receptor from Homo sapiens

Seq: 372 a.a.

Struc: 289 a.a.*

Protein chain

P63096  (GNAI1_HUMAN) -  Guanine nucleotide-binding protein G(i) subunit alpha-1 from Homo sapiens

Seq: 354 a.a.

Struc: 221 a.a.*

Protein chain

P54311  (GBB1_RAT) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Rattus norvegicus

Seq: 340 a.a.

Struc: 338 a.a.

Protein chain

P63212  (GBG2_BOVIN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Bos taurus

Seq: 71 a.a.

Struc: 57 a.a.

Protein chain

P63096  (GNAI1_HUMAN) -  Guanine nucleotide-binding protein G(i) subunit alpha-1 from Homo sapiens

Seq: 354 a.a.

Struc: 19 a.a.

* PDB and UniProt seqs differ at 9 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chains A, F: E.C.3.6.5.- - ?????