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UniProt functional annotation for P0ABJ6 | ||
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| UniProt code: P0ABJ6. |
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| Organism: | |
Escherichia coli (strain K12). |
| Taxonomy: | |
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia. |
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| Function: | |
Cytochrome bo(3) ubiquinol terminal oxidase is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration. Has proton pump activity across the membrane in addition to electron transfer, pumping 2 protons/electron. {ECO:0000269|PubMed:19542282, ECO:0000269|PubMed:22843529, ECO:0000269|PubMed:6308657}. |
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| Subunit: | |
Heterooctamer of two A chains, two B chains, two C chains and two D chains. {ECO:0000269|PubMed:11017202, ECO:0000269|PubMed:6308657}. |
| Subcellular location: | |
Cell inner membrane; Multi-pass membrane protein. |
| Disruption phenotype: | |
Increased reduction of the ubiquinone pool (in aerobically grown minimal medium with glucose). {ECO:0000269|PubMed:19542282, ECO:0000269|PubMed:22843529}. |
| Similarity: | |
Belongs to the cytochrome c oxidase bacterial subunit 4 family. {ECO:0000305}. |
| Sequence caution: | |
Sequence=AAB40185.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.