UniProt functional annotation for P07700



	UniProt functional annotation for P07700

UniProt code: P07700.

Organism: Meleagris gallopavo (Wild turkey).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Meleagridinae; Meleagris.

Function: Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity (PubMed:18594507). In dorsal pons neurons, involved in the regulation of sleep/wake behaviors (By similarity). {ECO:0000250|UniProtKB:P34971, ECO:0000269|PubMed:18594507}.

Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P18090}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P18090}. Early endosome {ECO:0000250}. Note=Colocalizes with RAPGEF2 at the plasma membrane. Found in the Golgi upon GOPC overexpression (By similarity). {ECO:0000250}.

Ptm: Homologous desensitization of the receptor is mediated by its phosphorylation by beta-adrenergic receptor kinase.

Similarity: Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB1 sub-subfamily. {ECO:0000255|PROSITE-ProRule:PRU00521}.

Annotations taken from UniProtKB at the EBI.


Organism:		Meleagris gallopavo (Wild turkey).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Meleagridinae; Meleagris.



Function:		Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity (PubMed:18594507). In dorsal pons neurons, involved in the regulation of sleep/wake behaviors (By similarity). {ECO:0000250\|UniProtKB:P34971, ECO:0000269\|PubMed:18594507}.


Subcellular location:		Cell membrane {ECO:0000250\|UniProtKB:P18090}; Multi-pass membrane protein {ECO:0000250\|UniProtKB:P18090}. Early endosome {ECO:0000250}. Note=Colocalizes with RAPGEF2 at the plasma membrane. Found in the Golgi upon GOPC overexpression (By similarity). {ECO:0000250}.
Ptm:		Homologous desensitization of the receptor is mediated by its phosphorylation by beta-adrenergic receptor kinase.
Similarity:		Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB1 sub-subfamily. {ECO:0000255\|PROSITE-ProRule:PRU00521}.