PDBsum entry 8zw0

Membrane protein

PDB id: 8zw0

Contents

Protein chains

236 a.a.

338 a.a.

305 a.a.

57 a.a.

128 a.a.

Ligands

CLR ×2

PG2

PDB id:

8zw0

Name:

Membrane protein

Title:

Cryo-em strcuture of prostaglandin d2 receptor dp1 activated by pgd2

Structure:

Guanine nucleotide-binding protein g(s) subunit alpha isoforms short. Chain: a. Synonym: adenylate cyclase-stimulating g alpha protein. Engineered: yes. Mutation: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: gnas, gnas1, gsp. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: gnb1. Escherichia coli, homo sapiens. Organism_taxid: 562, 9606.

Authors:

J.Xu,Y.Xu,C.Wu,H.E.Xu

Date:

12-Jun-24 Release date: 28-May-25

Protein chain

P63092  (GNAS2_HUMAN) -  Guanine nucleotide-binding protein G(s) subunit alpha isoforms short from Homo sapiens

Seq: 394 a.a.

Struc: 236 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 338 a.a.

Protein chain

P0ABE7  (C562_ECOLX) -  Soluble cytochrome b562 from Escherichia coli

Seq: 128 a.a.

Struc: 305 a.a.*

Protein chain

Q13258  (PD2R_HUMAN) -  Prostaglandin D2 receptor from Homo sapiens

Seq: 359 a.a.

Struc: 305 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 57 a.a.

Protein chain

No UniProt id for this chain

Struc: 128 a.a.

* PDB and UniProt seqs differ at 72 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????