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PDBsum entry 8zpn

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protein ligands Protein-protein interface(s) links
Signaling protein PDB id
8zpn

 

 

 

 

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Contents
Protein chains
282 a.a.
116 a.a.
Ligands
CLR
VH6
PDB id:
8zpn
Name: Signaling protein
Title: Cryo-em strucutre of cxcr4 complexed with antagonist amd3100
Structure: Soluble cytochrome b562,c-x-c chemokine receptor type 4. Chain: r. Synonym: cytochrome b-562,cxc-r4,cxcr-4,fb22,fusin,hm89,lcr1, leukocyte-derived seven transmembrane domain receptor,lestr, lipopolysaccharide-associated protein 3,lap-3,lps-associated protein 3,npyrl,stromal cell-derived factor 1 receptor,sdf-1 receptor. Engineered: yes. Nb6 nanobody. Chain: n.
Source: Escherichia coli, homo sapiens. Human. Organism_taxid: 562, 9606. Gene: cybc, cxcr4. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Lama glama. Organism_taxid: 9844. Expression_system_taxid: 7108
Authors: H.Z.Jiao,H.L.Hu
Key ref: X.H.Sang et al. Structural mechanisms underlying the modulation of cx diverse antagonists.. To be published, . PubMed id: 40063796
Date:
30-May-24     Release date:   26-Feb-25    
PROCHECK
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 Headers
 References

Protein chain
P61073  (CXCR4_HUMAN) -  C-X-C chemokine receptor type 4 from Homo sapiens
Seq:
Struc:
352 a.a.
282 a.a.*
Protein chain
No UniProt id for this chain
Struc: 116 a.a.
Key:    Secondary structure
* PDB and UniProt seqs differ at 21 residue positions (black crosses)

 

 

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