PDBsum entry 8zjg

Membrane protein

PDB id: 8zjg

Contents

Protein chains

320 a.a.

337 a.a.

223 a.a.

56 a.a.

233 a.a.

105 a.a.

Ligands

CLR ×4

Waters ×1

PDB id:

8zjg

Name:

Membrane protein

Title:

Cryo-em structure of human cmklr1-gi complex bound to chemerin

Structure:

Chemerin-like receptor 1. Chain: a. Synonym: chemokine-like receptor 1,g-protein coupled receptor chemr23,g-protein coupled receptor dez. Engineered: yes. Mutation: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: cmklr1, chemr23, dez. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: gnb1. Gene: gnai1. Gene: gng2.

Authors:

A.J.Liu,Y.Z.Liu,R.D.Ye

Key ref:

A.Liu et al. (2024). Structural basis for full-Length chemerin recognition signaling through chemerin receptor 1.. Commun biol, 7, 1598. PubMed id: 39616240

Date:

14-May-24 Release date: 22-Jan-25

Protein chain

Q99788  (CML1_HUMAN) -  Chemerin-like receptor 1 from Homo sapiens

Seq: 373 a.a.

Struc: 320 a.a.

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 337 a.a.

Protein chain

P63096  (GNAI1_HUMAN) -  Guanine nucleotide-binding protein G(i) subunit alpha-1 from Homo sapiens

Seq: 354 a.a.

Struc: 223 a.a.*

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 56 a.a.

Protein chain

No UniProt id for this chain

Struc: 233 a.a.

Protein chain

Q99969  (RARR2_HUMAN) -  Retinoic acid receptor responder protein 2 from Homo sapiens

Seq: 163 a.a.

Struc: 105 a.a.

* PDB and UniProt seqs differ at 2 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain C: E.C.3.6.5.- - ?????