PDBsum entry 8zje

Membrane protein

PDB id: 8zje

Contents

Protein chains

227 a.a.

338 a.a.

54 a.a.

279 a.a.

229 a.a.

11 a.a.

PDB id:

8zje

Name:

Membrane protein

Title:

Cryo-em structure of kisspeptin receptor bound to tak-448

Structure:

Guanine nucleotide-binding protein g(i) subunit alpha-1, guanine nucleotide-binding protein g(q) subunit alpha. Chain: a. Synonym: adenylate cyclase-inhibiting g alpha protein,guanine nucleotide-binding protein alpha-q. Engineered: yes. Other_details: fusion protein of guanine nucleotide-binding protein g(i) subunit alpha-1 and guanine nucleotide-binding protein g(q) subunit alpha-q..

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: gnai1, gnaq, gaq. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: gnb1. Gene: gng2. Gene: kiss1r, axor12, gpr54.

Authors:

S.Shen,H.Liu,H.E.Xu

Key ref:

S.Shen et al. Cryo-Em structure of kisspeptin receptor bound to tak. To be published, . PubMed id: 38935498

Date:

14-May-24 Release date: 03-Jul-24

Protein chain

P50148  (GNAQ_HUMAN) -  Guanine nucleotide-binding protein G(q) subunit alpha from Homo sapiens

Seq: 359 a.a.

Struc: 227 a.a.*

Protein chain

P63096  (GNAI1_HUMAN) -  Guanine nucleotide-binding protein G(i) subunit alpha-1 from Homo sapiens

Seq: 354 a.a.

Struc: 227 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 338 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 54 a.a.

Protein chain

Q969F8  (KISSR_HUMAN) -  KiSS-1 receptor from Homo sapiens

Seq: 398 a.a.

Struc: 279 a.a.*

Protein chain

No UniProt id for this chain

Struc: 229 a.a.

Protein chain

No UniProt id for this chain

Struc: 10 a.a.

* PDB and UniProt seqs differ at 140 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????