PDBsum entry 8zh8

Membrane protein/immune system

PDB id: 8zh8

Contents

Protein chains

325 a.a.

128 a.a.

337 a.a.

51 a.a.

220 a.a.

231 a.a.

25 a.a.

PDB id:

8zh8

Name:

Membrane protein/immune system

Title:

Human gpr103 -gq complex bound to qrfp26

Structure:

Pyroglutamylated rf-amide peptide receptor. Chain: r. Synonym: aq27,g-protein coupled receptor 103,orexigenic neuropeptide qrfp receptor,sp9155. Engineered: yes. Nanobody nb35. Chain: n. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: qrfpr, gpr103. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293s gnti-. Lama glama. Organism_taxid: 9844.

Authors:

A.Iwama,H.Akasaka,F.K.Sano,H.S.Oshima,W.Shihoya,O.Nureki

Key ref:

A.Iwama et al. (2024). Structure and dynamics of the pyroglutamylated rf-Ami peptide qrfp receptor gpr103.. Nat commun, 15, 4769. PubMed id: 38897996

Date:

10-May-24 Release date: 03-Jul-24

Protein chain

No UniProt id for this chain

Struc: 325 a.a.

Protein chain

No UniProt id for this chain

Struc: 128 a.a.

Protein chain

No UniProt id for this chain

Struc: 337 a.a.

Protein chain

No UniProt id for this chain

Struc: 51 a.a.

Protein chain

P12497  (POL_HV1N5) -  Gag-Pol polyprotein from Human immunodeficiency virus type 1 group M subtype B (isolate NY5)

Seq: 1435 a.a.

Struc: 220 a.a.*

Protein chain

No UniProt id for this chain

Struc: 231 a.a.

Protein chain

No UniProt id for this chain

Struc: 25 a.a.

* PDB and UniProt seqs differ at 197 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????