PDBsum entry 8zcj

Membrane protein/immune system

PDB id: 8zcj

Contents

Protein chains

222 a.a.

341 a.a.

50 a.a.

233 a.a.

275 a.a.

Ligands

004-DTR-LYS-TYR-PHA-HYP

PDB id:

8zcj

Name:

Membrane protein/immune system

Title:

Cryo-em structure of the pasireotide-bound sstr5-gi complex

Structure:

Guanine nucleotide-binding protein g(i) subunit alpha-1. Chain: b. Synonym: adenylate cyclase-inhibiting g alpha protein. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: c. Synonym: transducin beta chain 1. Engineered: yes.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: gnai1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Rattus norvegicus. Norway rat. Organism_taxid: 10116.

Authors:

Y.G.Li,X.Y.Meng,X.R.Yang,S.L.Ling,P.Shi,C.L.Tian,F.Yang

Key ref:

Y.G.Li et al. Structural insights into somatostatin receptor 5 boun cyclic peptides.. Acta pharmacol sin, . PubMed id: 38926478

Date:

29-Apr-24 Release date: 10-Jul-24

Protein chain

P63096  (GNAI1_HUMAN) -  Guanine nucleotide-binding protein G(i) subunit alpha-1 from Homo sapiens

Seq: 354 a.a.

Struc: 222 a.a.*

Protein chain

P54311  (GBB1_RAT) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Rattus norvegicus

Seq: 340 a.a.

Struc: 341 a.a.

Protein chain

P63212  (GBG2_BOVIN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Bos taurus

Seq: 71 a.a.

Struc: 50 a.a.

Protein chain

No UniProt id for this chain

Struc: 233 a.a.

Protein chain

P07550  (ADRB2_HUMAN) -  Beta-2 adrenergic receptor from Homo sapiens

Seq: 413 a.a.

Struc: 275 a.a.*

Protein chain

P35346  (SSR5_HUMAN) -  Somatostatin receptor type 5 from Homo sapiens

Seq: 364 a.a.

Struc: 275 a.a.

* PDB and UniProt seqs differ at 194 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain B: E.C.3.6.5.- - ?????