PDBsum entry 8z74

Signaling protein

PDB id: 8z74

Contents

Protein chains

130 a.a.

295 a.a.

Ligands

CLR ×2

PDB id:

8z74

Name:

Signaling protein

Title:

Cryo-em structure of apjr complex with agonistic antibody

Structure:

Agonistic antibody. Chain: a, b. Engineered: yes. Soluble cytochrome b562,apelin receptor. Chain: c, d. Synonym: cytochrome b-562,angiotensin receptor-like 1,g-protein coupled receptor apj,g-protein coupled receptor hg11. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: cybc, aplnr, agtrl1, apj. Expression_system_taxid: 7111

Authors:

Y.Yue,L.E.Liu,L.J.Wu,F.Xu

Key ref:

Y.Yue et al. (2025). Structural insights into the regulation of monomeric dimeric apelin receptor.. Nat commun, 16, 310. PubMed id: 39747115

Date:

19-Apr-24 Release date: 22-Jan-25

Protein chains

No UniProt id for this chain

Struc: 130 a.a.

Protein chains

P35414  (APJ_HUMAN) -  Apelin receptor from Homo sapiens

Seq: 380 a.a.

Struc: 295 a.a.