PDBsum entry 8yw4

Structural protein

PDB id: 8yw4

Contents

Protein chains

235 a.a.

341 a.a.

57 a.a.

129 a.a.

293 a.a.

27 a.a.

PDB id:

8yw4

Name:

Structural protein

Title:

Cryo-em structure of the retatrutide-bound human gipr-gs complex

Structure:

Mini-gs. Chain: a. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b. Synonym: transducin beta chain 1. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit

Source:

Homo sapiens. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Human. Gene: gnb1. Gene: gng2. Synthetic construct. Organism_taxid: 32630.

Authors:

W.Z.Li,Q.T.Zhou,Z.T.Cong,Q.N.Yuan,W.X.Li,F.H.Zhao,H.E.Xu,L.H.Zhao, D.H.Yang,M.W.Wang

Key ref:

W.Z.Li et al. Structural insights into the triple agonism at glp-1r and gcgr manifested by retatrutide. Cell discovery, . PubMed id: 39019866

Date:

29-Mar-24 Release date: 18-Sep-24

Protein chain

P63092  (GNAS2_HUMAN) -  Guanine nucleotide-binding protein G(s) subunit alpha isoforms short from Homo sapiens

Seq: 394 a.a.

Struc: 235 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 341 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 57 a.a.

Protein chain

No UniProt id for this chain

Struc: 129 a.a.

Protein chain

P48546  (GIPR_HUMAN) -  Gastric inhibitory polypeptide receptor from Homo sapiens

Seq: 466 a.a.

Struc: 293 a.a.*

Protein chain

No UniProt id for this chain

Struc: 27 a.a.

* PDB and UniProt seqs differ at 77 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????