PDBsum entry 8yuu

Membrane protein/immune system

PDB id: 8yuu

Contents

Protein chains

289 a.a.

225 a.a.

339 a.a.

58 a.a.

234 a.a.

Ligands

HSM

CLR

PDB id:

8yuu

Name:

Membrane protein/immune system

Title:

Cryo-em structure of the histamine-bound h3r-gi complex

Structure:

Histamine h3 receptor. Chain: r. Synonym: h3r,hh3r,g-protein coupled receptor 97. Engineered: yes. Guanine nucleotide-binding protein g(i) subunit alpha-1. Chain: a. Synonym: adenylate cyclase-inhibiting g alpha protein. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: hrh3, gpcr97. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell: sf9. Gene: gnai1. Gene: gnb1.

Authors:

Q.Shen,X.Tang,X.Wen,S.Cheng,P.Xiao,S.Zang,D.Shen,L.Jiang,Y.Zheng, H.Zhang,H.Xu,C.Mao,M.Zhang,W.Hu,J.Sun,Z.Chen,Y.Zhang

Key ref:

Q.Shen et al. Molecular determinant underlying selective coupling o primary g-Protein by class a gpcrs.. Adv sci, . PubMed id: 38647423

Date:

27-Mar-24 Release date: 05-Jun-24

Protein chain

Q9Y5N1  (HRH3_HUMAN) -  Histamine H3 receptor from Homo sapiens

Seq: 445 a.a.

Struc: 289 a.a.

Protein chain

P63096  (GNAI1_HUMAN) -  Guanine nucleotide-binding protein G(i) subunit alpha-1 from Homo sapiens

Seq: 354 a.a.

Struc: 225 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 339 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 58 a.a.

Protein chain

No UniProt id for this chain

Struc: 234 a.a.

* PDB and UniProt seqs differ at 4 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????