PDBsum entry 8yn4

Signaling protein

PDB id: 8yn4

Contents

Protein chains

229 a.a.

342 a.a.

57 a.a.

231 a.a.

268 a.a.

Ligands

HSM

CLR

PDB id:

8yn4

Name:

Signaling protein

Title:

Cryo-em structure of histamine h2 receptor in complex with histamine and minigq

Structure:

Engineered guanine nucleotide-binding protein g(q) subunit alpha. Chain: a. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit

Source:

Synthetic construct. Organism_taxid: 32630. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Homo sapiens. Human. Organism_taxid: 9606. Gene: gnb1. Gene: gng2.

Authors:

X.Zhang,G.Liu,X.Li,W.Gong

Key ref:

X.Zhang et al. (2024). Structural basis of ligand recognition and activation histamine receptor family. Nat commun, 15, 8296. PubMed id: 39333117

Date:

10-Mar-24 Release date: 09-Oct-24

Protein chain

No UniProt id for this chain

Struc: 229 a.a.

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 342 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 57 a.a.

Protein chain

No UniProt id for this chain

Struc: 231 a.a.

Protein chain

P25021  (HRH2_HUMAN) -  Histamine H2 receptor from Homo sapiens

Seq: 359 a.a.

Struc: 268 a.a.