PDBsum entry 8ykw

Membrane protein/immune system

PDB id: 8ykw

Contents

Protein chains

213 a.a.

337 a.a.

232 a.a.

58 a.a.

284 a.a.

Ligands

SIN

PDB id:

8ykw

Name:

Membrane protein/immune system

Title:

Cryo-em structure of succinate receptor sucr1 bound to succinic acid

Structure:

Guanine nucleotide-binding protein g(i) subunit alpha-1. Chain: a. Synonym: adenylate cyclase-inhibiting g alpha protein. Engineered: yes. Mutation: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b. Synonym: transducin beta chain 1.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: gnai1. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Rattus norvegicus. Norway rat. Organism_taxid: 10116.

Authors:

C.Li,H.Liu,J.Li,H.Zhu,W.Fu,H.E.Xu

Key ref:

C.Li et al. Cryo-Em structure of succinate receptor sucr1 bound t succinic acid. To be published, . PubMed id: 38834763

Date:

05-Mar-24 Release date: 29-May-24

Protein chain

P63096  (GNAI1_HUMAN) -  Guanine nucleotide-binding protein G(i) subunit alpha-1 from Homo sapiens

Seq: 354 a.a.

Struc: 213 a.a.*

Protein chain

P54311  (GBB1_RAT) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Rattus norvegicus

Seq: 340 a.a.

Struc: 337 a.a.

Protein chain

No UniProt id for this chain

Struc: 232 a.a.

Protein chain

P63212  (GBG2_BOVIN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Bos taurus

Seq: 71 a.a.

Struc: 58 a.a.

Protein chain

Q9BXA5  (SUCR1_HUMAN) -  Succinate receptor 1 from Homo sapiens

Seq: 334 a.a.

Struc: 284 a.a.

* PDB and UniProt seqs differ at 3 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????