PDBsum entry 8y52

Membrane protein

PDB id: 8y52

Contents

Protein chains

232 a.a.

338 a.a.

54 a.a.

299 a.a.

Ligands

DPN-GLN-TRP-ALA-VAL-BAL-HIS-PHE-NLE

PDB id:

8y52

Name:

Membrane protein

Title:

Cryo-em structure of the ba1-bound brs3-gq complex

Structure:

Guanine nucleotide-binding protein g(q) subunit alpha. Chain: a. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b. Synonym: transducin beta chain 1. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit

Source:

Homo sapiens. Human. Organism_taxid: 9606. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: gnb1. Gene: gng2. Gene: brs3. Synthetic: yes.

Authors:

C.Li,Y.Xu,W.Yin,H.E.Xu

Key ref:

C.Li et al. (2024). Structural insights into ligand recognition, Selectiv and activation of bombesin receptor subtype-3.. Cell rep, 43, 14511. PubMed id: 39024101

Date:

31-Jan-24 Release date: 11-Sep-24

Protein chain

P50148  (GNAQ_HUMAN) -  Guanine nucleotide-binding protein G(q) subunit alpha from Homo sapiens

Seq: 359 a.a.

Struc: 232 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 338 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 54 a.a.

Protein chain

P32247  (BRS3_HUMAN) -  Bombesin receptor subtype-3 from Homo sapiens

Seq: 399 a.a.

Struc: 299 a.a.

* PDB and UniProt seqs differ at 137 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????