PDBsum entry 8xyd

Membrane protein

PDB id: 8xyd

Contents

Protein chains

303 a.a.

336 a.a.

54 a.a.

217 a.a.

232 a.a.

Ligands

PFS

PDB id:

8xyd

Name:

Membrane protein

Title:

Structure of platelet-activating factor receptor-g protein complex bound to platelet-activating factor

Structure:

Platelet-activating factor receptor. Chain: a. Synonym: paf-r,pafr. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b. Synonym: transducin beta chain 1. Engineered: yes.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: ptafr, pafr. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: gnb1. Gene: gng2. Gene: gnai1.

Authors:

W.Fan,Y.Xu,Y.Zhuang,H.E.Xu

Key ref:

W.Fan et al. (2024). Molecular basis for the activation of paf receptor by. Cell rep, 43, 14422. PubMed id: 38943642 DOI: 10.1016/J.CELREP.2024.114422

Date:

19-Jan-24 Release date: 13-Nov-24

Protein chain

P25105  (PTAFR_HUMAN) -  Platelet-activating factor receptor from Homo sapiens

Seq: 342 a.a.

Struc: 303 a.a.

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 336 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 54 a.a.

Protein chain

P63096  (GNAI1_HUMAN) -  Guanine nucleotide-binding protein G(i) subunit alpha-1 from Homo sapiens

Seq: 354 a.a.

Struc: 217 a.a.*

Protein chain

No UniProt id for this chain

Struc: 232 a.a.

* PDB and UniProt seqs differ at 2 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain D: E.C.3.6.5.- - ?????