PDBsum entry 8xxx

Signaling protein/immune system

PDB id: 8xxx

Contents

Protein chains

65 a.a.

298 a.a.

211 a.a.

336 a.a.

53 a.a.

233 a.a.

PDB id:

8xxx

Name:

Signaling protein/immune system

Title:

Structure of cxcr2 bound to cxcl6 (composite map)

Structure:

C-x-c motif chemokine 6. Chain: d. Synonym: chemokine alpha 3,cka-3,granulocyte chemotactic protein 2, gcp-2,small-inducible cytokine b6. Engineered: yes. C-x-c chemokine receptor type 2. Chain: r. Synonym: cxc-r2,cxcr-2. Engineered: yes.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: cxcl6, gcp2, scyb6. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: cxcr2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.

Authors:

F.K.Sano,S.Saha,S.Sharma,M.Ganguly,W.Shihoya,O.Nureki,A.K.Shukla, R.Banerjee

Key ref:

F.K.Sano et al. Structure of cxcr2 bound to cxcl6 (composite map). To be published, . PubMed id: 39978339

Date:

19-Jan-24 Release date: 15-Jan-25

Protein chain

P80162  (CXCL6_HUMAN) -  C-X-C motif chemokine 6 from Homo sapiens

Seq: 114 a.a.

Struc: 65 a.a.

Protein chain

P25025  (CXCR2_HUMAN) -  C-X-C chemokine receptor type 2 from Homo sapiens

Seq: 360 a.a.

Struc: 298 a.a.

Protein chain

P09471  (GNAO_HUMAN) -  Guanine nucleotide-binding protein G(o) subunit alpha from Homo sapiens

Seq: 354 a.a.

Struc: 211 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 336 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 53 a.a.

Protein chain

No UniProt id for this chain

Struc: 233 a.a.

* PDB and UniProt seqs differ at 6 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????