PDBsum entry 8xx7

Signaling protein/immune system

PDB id: 8xx7

Contents

Protein chains

65 a.a.

300 a.a.

215 a.a.

336 a.a.

53 a.a.

PDB id:

8xx7

Name:

Signaling protein/immune system

Title:

Structure of cxcr2 bound to cxcl5 (cxcr2-cxcl5-go full map)

Structure:

C-x-c motif chemokine 5. Chain: d, b. Engineered: yes. C-x-c chemokine receptor type 2. Chain: r, c. Synonym: cxc-r2,cxcr-2. Engineered: yes. Guanine nucleotide-binding protein g(o) subunit alpha. Chain: a, f.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: cxcl5. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: cxcr2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.

Authors:

F.K.Sano,S.Saha,S.Sharma,M.Ganguly,W.Shihoya,O.Nureki,A.K.Shukla, R.Banerjee

Key ref:

F.K.Sano et al. Structure of cxcr2 bound to cxcl5 (cxcr2-Cxcl5-Go ful. To be published, . PubMed id: 39978339

Date:

17-Jan-24 Release date: 15-Jan-25

Protein chains

P42830  (CXCL5_HUMAN) -  C-X-C motif chemokine 5 from Homo sapiens

Seq: 114 a.a.

Struc: 65 a.a.

Protein chains

P25025  (CXCR2_HUMAN) -  C-X-C chemokine receptor type 2 from Homo sapiens

Seq: 360 a.a.

Struc: 300 a.a.

Protein chains

P09471  (GNAO_HUMAN) -  Guanine nucleotide-binding protein G(o) subunit alpha from Homo sapiens

Seq: 354 a.a.

Struc: 215 a.a.*

Protein chains

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 336 a.a.

Protein chains

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 53 a.a.

* PDB and UniProt seqs differ at 6 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chains A, F: E.C.3.6.5.- - ?????