PDBsum entry 8xwv

Signaling protein/immune system

PDB id: 8xwv

Contents

Protein chains

68 a.a.

61 a.a.

296 a.a.

207 a.a.

338 a.a.

56 a.a.

231 a.a.

PDB id:

8xwv

Name:

Signaling protein/immune system

Title:

Structure of cxcr2 bound to cxcl1 (cxcr2-cxcl1-go full map)

Structure:

Growth-regulated alpha protein. Chain: d, e. Synonym: gro-alpha(1-73). Engineered: yes. C-x-c chemokine receptor type 2. Chain: r. Synonym: cxc-r2,cxcr-2. Engineered: yes. Guanine nucleotide-binding protein g(o) subunit alpha.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: cxcl1. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: cxcr2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.

Authors:

F.K.Sano,S.Saha,S.Sharma,M.Ganguly,W.Shihoya,O.Nureki,A.K.Shukla, R.Banerjee

Key ref:

F.K.Sano et al. Structure of cxcr2 bound to cxcl1 (cxcr2-Cxcl1-Go ful. To be published, . PubMed id: 39978339

Date:

16-Jan-24 Release date: 22-Jan-25

Protein chain

P09341  (GROA_HUMAN) -  Growth-regulated alpha protein from Homo sapiens

Seq: 107 a.a.

Struc: 68 a.a.

Protein chain

P09341  (GROA_HUMAN) -  Growth-regulated alpha protein from Homo sapiens

Seq: 107 a.a.

Struc: 61 a.a.

Protein chain

P25025  (CXCR2_HUMAN) -  C-X-C chemokine receptor type 2 from Homo sapiens

Seq: 360 a.a.

Struc: 296 a.a.

Protein chain

P09471  (GNAO_HUMAN) -  Guanine nucleotide-binding protein G(o) subunit alpha from Homo sapiens

Seq: 354 a.a.

Struc: 207 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 338 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 56 a.a.

Protein chain

No UniProt id for this chain

Struc: 231 a.a.

* PDB and UniProt seqs differ at 6 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????