PDBsum entry 8xwp

Membrane protein

PDB id: 8xwp

Contents

Protein chains

302 a.a.

21 a.a.

218 a.a.

338 a.a.

53 a.a.

231 a.a.

PDB id:

8xwp

Name:

Membrane protein

Title:

Cryo-em structure of et-1 bound etbr-dngi complex

Structure:

Endothelin receptor type b. Chain: r. Synonym: et-b,et-br,endothelin receptor non-selective type. Engineered: yes. Endothelin-1. Chain: l. Synonym: preproendothelin-1,ppet1. Engineered: yes. Guanine nucleotide-binding protein g(i) subunit alpha-1.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: ednrb, etrb. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: edn1. Gene: gnai1. Gene: gnb1.

Authors:

K.Tani,S.Maki-Yonekura,R.Kanno,T.Negami,T.Hamaguchi,M.Hall, A.Mizoguchi,B.M.Humbel,T.Terada,K.Yonekura,T.Doi

Key ref:

K.Tani et al. Structure of endothelin etb receptor-Gi complex in a conformation stabilized by the unique npxxl motif. Commun biol, . PubMed id: 39414992

Date:

16-Jan-24 Release date: 02-Oct-24

Protein chain

P24530  (EDNRB_HUMAN) -  Endothelin receptor type B from Homo sapiens

Seq: 442 a.a.

Struc: 302 a.a.*

Protein chain

P05305  (EDN1_HUMAN) -  Endothelin-1 from Homo sapiens

Seq: 212 a.a.

Struc: 21 a.a.

Protein chain

P63096  (GNAI1_HUMAN) -  Guanine nucleotide-binding protein G(i) subunit alpha-1 from Homo sapiens

Seq: 354 a.a.

Struc: 218 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 338 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 53 a.a.

Protein chain

No UniProt id for this chain

Struc: 231 a.a.

* PDB and UniProt seqs differ at 6 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????