PDBsum entry 8xqe

Signaling protein

PDB id: 8xqe

Contents

Protein chains

224 a.a.

339 a.a.

59 a.a.

296 a.a.

234 a.a.

13 a.a.

277 a.a.

PDB id:

8xqe

Name:

Signaling protein

Title:

Cryo-em structure of human dimeric apjr-gi complex with apelin-13.

Structure:

G protein subunit alpha i1. Chain: a. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b. Synonym: transducin beta chain 1,g protein beta subunit. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: gnai1. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: gnb1. Gene: gng2. Gene: cybc, aplnr, agtrl1, apj.

Authors:

Y.Yue,L.E.Liu,L.J.Wu,F.Xu

Key ref:

Y.Yue et al. (2025). Structural insights into the regulation of monomeric dimeric apelin receptor.. Nat commun, 16, 310. PubMed id: 39747115

Date:

05-Jan-24 Release date: 22-Jan-25

Protein chain

P63096  (GNAI1_HUMAN) -  Guanine nucleotide-binding protein G(i) subunit alpha-1 from Homo sapiens

Seq: 354 a.a.

Struc: 224 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 339 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 59 a.a.

Protein chain

P35414  (APJ_HUMAN) -  Apelin receptor from Homo sapiens

Seq: 380 a.a.

Struc: 296 a.a.

Protein chain

No UniProt id for this chain

Struc: 234 a.a.

Protein chain

Q9ULZ1  (APEL_HUMAN) -  Apelin from Homo sapiens

Seq: 77 a.a.

Struc: 13 a.a.

Protein chain

P35414  (APJ_HUMAN) -  Apelin receptor from Homo sapiens

Seq: 380 a.a.

Struc: 277 a.a.

* PDB and UniProt seqs differ at 3 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????