PDBsum entry 8xoi

Membrane protein/immune system

PDB id: 8xoi

Contents

Protein chains

228 a.a.

338 a.a.

228 a.a.

57 a.a.

264 a.a.

PDB id:

8xoi

Name:

Membrane protein/immune system

Title:

Cryo-em structure of gpr30-gq complex structure in the presence of fulvestrant

Structure:

Guanine nucleotide-binding protein g(q) subunit alpha-q. Chain: a. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b. Synonym: transducin beta chain 1. Engineered: yes. Scfv16.

Source:

Homo sapiens. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: gnb1. Synthetic construct. Organism_taxid: 32630. Gene: gng2. Gene: gper1, cepr, cmkrl2, dry12, gper, gpr30.

Authors:

H.Liu,P.Xu,H.E.Xu

Key ref:

H.Liu et al. Cryo-Em structure of gpr30-Gq complex structure in th presence of fulvestrant. To be published, . PubMed id: 38744981

Date:

01-Jan-24 Release date: 10-Apr-24

Protein chain

P63092  (GNAS2_HUMAN) -  Guanine nucleotide-binding protein G(s) subunit alpha isoforms short from Homo sapiens

Seq: 394 a.a.

Struc: 228 a.a.*

Protein chain

P63096  (GNAI1_HUMAN) -  Guanine nucleotide-binding protein G(i) subunit alpha-1 from Homo sapiens

Seq: 354 a.a.

Struc: 228 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 338 a.a.

Protein chain

No UniProt id for this chain

Struc: 228 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 57 a.a.

Protein chain

Q99527  (GPER1_HUMAN) -  G-protein coupled estrogen receptor 1 from Homo sapiens

Seq: 375 a.a.

Struc: 264 a.a.

* PDB and UniProt seqs differ at 199 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????