PDBsum entry 8xgu

Structural protein/immune system

PDB id: 8xgu

Contents

Protein chains

287 a.a.

213 a.a.

337 a.a.

56 a.a.

233 a.a.

11 a.a.

PDB id:

8xgu

Name:

Structural protein/immune system

Title:

A peptide receptor complex structure

Structure:

Kiss-1 receptor. Chain: a. Synonym: kiss-1r,g-protein coupled receptor 54,g-protein coupled receptor ot7t175,hot7t175,hypogonadotropin-1,kisspeptins receptor, metastin receptor. Engineered: yes. Guanine nucleotide-binding protein g(i) subunit alpha-1. Chain: c. Synonym: adenylate cyclase-inhibiting g alpha protein.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: kiss1r, axor12, gpr54. Expressed in: spodoptera aff. Frugiperda 1 bold-2017. Expression_system_taxid: 2449148. Gene: gnai1. Gene: gnb1. Gene: gng2.

Authors:

Z.Wu,Y.Du,G.Chen

Key ref:

Z.Wu et al. (2024). Structural basis for the ligand recognition and g pro subtype selectivity of kisspeptin receptor.. Sci adv, 10, n7771. PubMed id: 39151001

Date:

15-Dec-23 Release date: 30-Oct-24

Protein chain

Q969F8  (KISSR_HUMAN) -  KiSS-1 receptor from Homo sapiens

Seq: 398 a.a.

Struc: 287 a.a.

Protein chain

P63096  (GNAI1_HUMAN) -  Guanine nucleotide-binding protein G(i) subunit alpha-1 from Homo sapiens

Seq: 354 a.a.

Struc: 213 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 337 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 56 a.a.

Protein chain

No UniProt id for this chain

Struc: 233 a.a.

Protein chain

No UniProt id for this chain

Struc: 10 a.a.

* PDB and UniProt seqs differ at 47 residue positions (black crosses)