PDBsum entry 8x8n

Signaling protein

PDB id: 8x8n

Contents

Protein chains

235 a.a.

338 a.a.

230 a.a.

54 a.a.

270 a.a.

Ligands

DPN-CYS-PHE-DTR-LYS-THR-CYS-THR

PDB id:

8x8n

Name:

Signaling protein

Title:

Cryo-em structure of the octreotide-bound somatostatin receptor 5-gi protein complex

Structure:

Guanine nucleotide-binding protein g(i) subunit alpha. Chain: a. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b. Synonym: transducin beta chain 1. Engineered: yes. Scfv16.

Source:

Homo sapiens. Organism_taxid: 9606. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Human. Gene: gnb1. Mus musculus. Organism_taxid: 10090. Gene: gng2.

Authors:

H.E.Xu,C.You,L.Zhao,J.Li

Key ref:

H.E.Xu and c.you Cryo-Em structure of the octreotide-Bound somatostati receptor 5-Gi protein complex. To be published, . PubMed id: 38885377

Date:

27-Nov-23 Release date: 12-Jun-24

Protein chain

No UniProt id for this chain

Struc: 235 a.a.

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 338 a.a.

Protein chain

No UniProt id for this chain

Struc: 230 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 54 a.a.

Protein chain

P35346  (SSR5_HUMAN) -  Somatostatin receptor type 5 from Homo sapiens

Seq: 364 a.a.

Struc: 270 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)