PDBsum entry 8x8l

Signaling protein

PDB id: 8x8l

Contents

Protein chains

236 a.a.

335 a.a.

12 a.a.

230 a.a.

55 a.a.

272 a.a.

PDB id:

8x8l

Name:

Signaling protein

Title:

Cryo-em structure of the cortistatin 17-bound somatostatin receptor 5- gi protein complex

Structure:

Guanine nucleotide-binding protein g(i) subunit alpha. Chain: a. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b. Synonym: transducin beta chain 1. Engineered: yes. Cortistatin.

Source:

Homo sapiens. Organism_taxid: 9606. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Human. Gene: gnb1. Synthetic: yes. Mus musculus. Organism_taxid: 10090.

Authors:

H.E.Xu,C.You,L.Zhao,J.Li

Key ref:

H.E.Xu and c.you Cryo-Em structure of the cortistatin 17-Bound somatos receptor 5-Gi protein complex. To be published, . PubMed id: 38885377

Date:

27-Nov-23 Release date: 12-Jun-24

Protein chain

No UniProt id for this chain

Struc: 236 a.a.

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 335 a.a.

Protein chain

O00230  (CORT_HUMAN) -  Cortistatin from Homo sapiens

Seq: 105 a.a.

Struc: 12 a.a.

Protein chain

No UniProt id for this chain

Struc: 230 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 55 a.a.

Protein chain

P35346  (SSR5_HUMAN) -  Somatostatin receptor type 5 from Homo sapiens

Seq: 364 a.a.

Struc: 272 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)