PDBsum entry 8x0b

Membrane protein

PDB id: 8x0b

Contents

Protein chains

780 a.a.

Ligands

NAG ×2

QUS ×2

XQT ×2

Waters ×33

PDB id:

8x0b

Name:

Membrane protein

Title:

Human fl metabotropic glutamate receptor 5, mglu5-5m with quisqualate and vu0424465

Structure:

Metabotropic glutamate receptor 5. Chain: a, b. Synonym: mglur5. Engineered: yes. Mutation: yes. Other_details: the construct has tags (flag and his) and protease cleavage site at its n-term (dykddddkhhhhhhhhhhlevlfqgp) and when compared to uniprot it starts at 21 and ends at 856. For cryoem, the tag is cleaved and the protein used for experiment starts at qsse but

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: grm5, gprc1e, mglur5. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293.

Authors:

K.R.Vinothkumar,G.Lebon,G.Cannone

Key ref:

K.R.Vinothkumar et al. Conformational diversity in class c gpcr positive all modulation. To be published, . PubMed id: 39805839

Date:

04-Nov-23 Release date: 06-Nov-24

Protein chains

P41594  (GRM5_HUMAN) -  Metabotropic glutamate receptor 5 from Homo sapiens

Seq: 1212 a.a.

Struc: 780 a.a.*

* PDB and UniProt seqs differ at 7 residue positions (black crosses)