PDBsum entry 8wwn

Membrane protein

PDB id: 8wwn

Contents

Protein chains

224 a.a.

342 a.a.

57 a.a.

231 a.a.

289 a.a.

17 a.a.

PDB id:

8wwn

Name:

Membrane protein

Title:

Mch-mchr1-gi complex,l1 state

Structure:

Guanine nucleotide-binding protein g(i) subunit alpha-1. Chain: a. Synonym: adenylate cyclase-inhibiting g alpha protein. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b. Synonym: transducin beta chain 1. Engineered: yes.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: gnai1. Expressed in: baculovirus expression vector pfastbac1-hm. Expression_system_taxid: 274590. Gene: gnb1. Gene: gng2. Synthetic construct.

Authors:

W.Gong,X.Ye,G.Liu

Key ref:

W.Gong et al. Structural insights into ligand recognition and activ of melanin-Concentrating hormone receptor mchr1. To be published, . PubMed id: 39616153

Date:

25-Oct-23 Release date: 13-Nov-24

Protein chain

P63096  (GNAI1_HUMAN) -  Guanine nucleotide-binding protein G(i) subunit alpha-1 from Homo sapiens

Seq: 354 a.a.

Struc: 224 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 342 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 57 a.a.

Protein chain

No UniProt id for this chain

Struc: 231 a.a.

Protein chain

Q99705  (MCHR1_HUMAN) -  Melanin-concentrating hormone receptor 1 from Homo sapiens

Seq: 353 a.a.

Struc: 289 a.a.

Protein chain

P20382  (MCH_HUMAN) -  Pro-MCH from Homo sapiens

Seq: 165 a.a.

Struc: 17 a.a.

* PDB and UniProt seqs differ at 4 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????