PDBsum entry 8wst

Membrane protein

PDB id: 8wst

Contents

Protein chains

230 a.a.

337 a.a.

57 a.a.

15 a.a.

129 a.a.

287 a.a.

PDB id:

8wst

Name:

Membrane protein

Title:

Cryo-em structure of melanin-concentrating hormone receptor 2 with mch

Structure:

Guanine nucleotide-binding protein g(q) subunit alpha-1. Chain: a. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2.

Source:

Homo sapiens. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Human. Gene: gnb1. Gene: gng2. Gene: pmch. Gene: mchr2.

Authors:

L.Zhao,Q.He,Q.Yuan,Y.Gu,H.Shan,W.Hu,K.Wu,H.E.Xu,Y.Zhang,C.Wu

Key ref:

Q.He et al. (2024). Mechanisms of ligand recognition and activation of melanin-Concentrating hormone receptors. Cell discov, 10, 48. PubMed id: 38710677

Date:

17-Oct-23 Release date: 19-Jun-24

Protein chain

No UniProt id for this chain

Struc: 230 a.a.

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 337 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 57 a.a.

Protein chain

P20382  (MCH_HUMAN) -  Pro-MCH from Homo sapiens

Seq: 165 a.a.

Struc: 15 a.a.

Protein chain

No UniProt id for this chain

Struc: 129 a.a.

Protein chain

Q969V1  (MCHR2_HUMAN) -  Melanin-concentrating hormone receptor 2 from Homo sapiens

Seq: 340 a.a.

Struc: 287 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)