PDBsum entry 8wss

Membrane protein

PDB id: 8wss

Contents

Protein chains

217 a.a.

339 a.a.

56 a.a.

231 a.a.

17 a.a.

283 a.a.

PDB id:

8wss

Name:

Membrane protein

Title:

Cryo-em structure of melanin-concentrating hormone receptor 1 with mch

Structure:

Guanine nucleotide-binding protein g(i) subunit alpha-1. Chain: a. Synonym: adenylate cyclase-inhibiting g alpha protein. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: gnai1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: gnb1. Gene: gng2. Mus musculus.

Authors:

L.Zhao,Q.He,Q.Yuan,Y.Gu,H.Shan,W.Hu,K.Wu,H.E.Xu,Y.Zhang,C.Wu

Key ref:

Q.He et al. (2024). Mechanisms of ligand recognition and activation of melanin-Concentrating hormone receptors. Cell discov, 10, 48. PubMed id: 38710677

Date:

17-Oct-23 Release date: 19-Jun-24

Protein chain

P63096  (GNAI1_HUMAN) -  Guanine nucleotide-binding protein G(i) subunit alpha-1 from Homo sapiens

Seq: 354 a.a.

Struc: 217 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 339 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 56 a.a.

Protein chain

No UniProt id for this chain

Struc: 231 a.a.

Protein chain

P20382  (MCH_HUMAN) -  Pro-MCH from Homo sapiens

Seq: 165 a.a.

Struc: 17 a.a.

Protein chain

Q99705  (MCHR1_HUMAN) -  Melanin-concentrating hormone receptor 1 from Homo sapiens

Seq: 353 a.a.

Struc: 283 a.a.

* PDB and UniProt seqs differ at 4 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????