PDBsum entry 8wog

Membrane protein

PDB id: 8wog

Contents

Protein chains

311 a.a.

228 a.a.

334 a.a.

56 a.a.

Ligands

SIN

Waters ×3

PDB id:

8wog

Name:

Membrane protein

Title:

Cryo-em structure of sucr1 in complex with succinate and gi protein

Structure:

Succinate receptor 1. Chain: a. Engineered: yes. Guanine nucleotide-binding protein g(i) subunit alpha-1. Chain: c. Synonym: adenylate cyclase-inhibiting g alpha protein. Engineered: yes. Mutation: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: sucnr1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: gnai1. Gene: gnb1. Gene: gng2.

Authors:

A.Liu,R.D.Ye

Key ref:

A.Liu et al. (2024). Structural insights into ligand recognition and activ of the succinate receptor sucnr1. Cell rep, 43, . PubMed id: 38923454

Date:

07-Oct-23 Release date: 11-Sep-24

Protein chain

Q9BXA5  (SUCR1_HUMAN) -  Succinate receptor 1 from Homo sapiens

Seq: 334 a.a.

Struc: 311 a.a.

Protein chain

P63096  (GNAI1_HUMAN) -  Guanine nucleotide-binding protein G(i) subunit alpha-1 from Homo sapiens

Seq: 354 a.a.

Struc: 228 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 334 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 56 a.a.

* PDB and UniProt seqs differ at 2 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain C: E.C.3.6.5.- - ?????