PDBsum entry 8wm9

Membrane protein

PDB id: 8wm9

Contents

Protein chains

320 a.a.

89 a.a.

Ligands

Y01 ×10

PDB id:

8wm9

Name:

Membrane protein

Title:

Fzd4/dep complex

Structure:

Frizzled-4. Chain: a, b. Engineered: yes. Segment polarity protein dishevelled homolog dvl-2. Chain: c. Synonym: dep. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: fzd4. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: dvl2. Expression_system_taxid: 7108

Authors:

Y.He,Y.Qian

Key ref:

Y.Qian et al. (2024). Structural basis of frizzled 4 in recognition of dish 2 unveils mechanism of wnt signaling activation.. Nat commun, 15, 7644. PubMed id: 39223191

Date:

03-Oct-23 Release date: 11-Sep-24

Protein chains

Q9ULV1  (FZD4_HUMAN) -  Frizzled-4 from Homo sapiens

Seq: 537 a.a.

Struc: 320 a.a.*

Protein chain

O14641  (DVL2_HUMAN) -  Segment polarity protein dishevelled homolog DVL-2 from Homo sapiens

Seq: 736 a.a.

Struc: 89 a.a.

* PDB and UniProt seqs differ at 4 residue positions (black crosses)