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PDBsum entry 8wkz
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Membrane protein
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PDB id
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8wkz
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PDB id:
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| Name: |
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Membrane protein
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Title:
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Crystal structure of the melanocortin-4 receptor (mc4r) in complex with s31
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Structure:
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Melanocortin receptor 4. Chain: a. Synonym: mc4-r. Engineered: yes. [N-(3-{bis[2-(pyridin-2-yl-kappan)ethyl]amino- kappan}propyl)-5-(2-oxohexahydro-1h-thieno[3,4-d]imidazol-4-yl) pentanamide](azido)(hydroxy)copper. Chain: b. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: mc4r. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Synthetic: yes. Synthetic construct. Organism_taxid: 32630
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Resolution:
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3.30Å
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R-factor:
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0.216
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R-free:
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0.272
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Authors:
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L.E.Gimenez,C.Martin,J.Yu,C.Hollanders,C.Hernandez,N.S.Dahir,Y.Wu, D.Yao,G.W.Han,L.Wu,O.V.Poorten,A.Lamouroux,M.Mannes,D.Tourwe,S.Zhao, R.C.Stevens,R.D.Cone,S.Ballet
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Key ref:
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L.E.Gimenez
et al.
(2024).
Novel cocrystal structures of peptide antagonists bou the human melanocortin receptor 4 unveil unexplored g for structure-Based drug design..
J med chem,
67,
2690.
PubMed id:
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Date:
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28-Sep-23
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Release date:
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07-Aug-24
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PROCHECK
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Headers
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References
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Links
