PDBsum entry 8wgb

Membrane protein

PDB id: 8wgb

Contents

Protein chains

338 a.a.

57 a.a.

762 a.a.

223 a.a.

763 a.a.

Ligands

GLU ×2

W9R

PDB id:

8wgb

Name:

Membrane protein

Title:

Mglu2-4 heterodimer bound with gi

Structure:

Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: d. Synonym: transducin beta chain 1. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2. Chain: e. Synonym: g gamma-i.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: gnb1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: gng2. Gene: grm2. Gene: gnai3.

Authors:

Y.Zhang,J.Liu

Key ref:

Y.Zhang and j.liu Structural basis of orientated asymmetry in a mglu heterodimer. To be published, . PubMed id: 39609406

Date:

20-Sep-23 Release date: 30-Oct-24

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 338 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 57 a.a.

Protein chain

Q14416  (GRM2_HUMAN) -  Metabotropic glutamate receptor 2 from Homo sapiens

Seq: 872 a.a.

Struc: 762 a.a.

Protein chain

P08754  (GNAI3_HUMAN) -  Guanine nucleotide-binding protein G(i) subunit alpha-3 from Homo sapiens

Seq: 354 a.a.

Struc: 223 a.a.*

Protein chain

Q14833  (GRM4_HUMAN) -  Metabotropic glutamate receptor 4 from Homo sapiens

Seq: 912 a.a.

Struc: 763 a.a.

* PDB and UniProt seqs differ at 4 residue positions (black crosses)