PDBsum entry 8wg8

Membrane protein

PDB id: 8wg8

Contents

Protein chains

234 a.a.

339 a.a.

56 a.a.

128 a.a.

263 a.a.

17 a.a.

PDB id:

8wg8

Name:

Membrane protein

Title:

Cryo-em structures of peptide free and gs-coupled gcgr

Structure:

Guanine nucleotide-binding protein g(s) subunit alpha isoforms short. Chain: a. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b. Synonym: transducin beta chain 1. Engineered: yes.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: gnb1.

Authors:

Z.T.Cong,F.H.Zhao,Y.Li,G.Luo,Q.T.Zhou,D.H.Yang,M.W.Wang

Key ref:

Z.Cong et al. (2024). Molecular features of the ligand-Free glp-1r, Gcgr an in complex with g s proteins.. Cell discov, 10, 18. PubMed id: 38346960

Date:

20-Sep-23 Release date: 06-Mar-24

Protein chain

P63092  (GNAS2_HUMAN) -  Guanine nucleotide-binding protein G(s) subunit alpha isoforms short from Homo sapiens

Seq: 394 a.a.

Struc: 234 a.a.*

Protein chain

P63096  (GNAI1_HUMAN) -  Guanine nucleotide-binding protein G(i) subunit alpha-1 from Homo sapiens

Seq: 354 a.a.

Struc: 234 a.a.*

Protein chain

P54311  (GBB1_RAT) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Rattus norvegicus

Seq: 340 a.a.

Struc: 339 a.a.

Protein chain

P63212  (GBG2_BOVIN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Bos taurus

Seq: 71 a.a.

Struc: 56 a.a.

Protein chain

No UniProt id for this chain

Struc: 128 a.a.

Protein chain

P47871  (GLR_HUMAN) -  Glucagon receptor from Homo sapiens

Seq: 477 a.a.

Struc: 263 a.a.

Protein chain

No UniProt id for this chain

Struc: 17 a.a.

* PDB and UniProt seqs differ at 197 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????