PDBsum entry 8w8y

Membrane protein

PDB id: 8w8y

Contents

Protein chains

260 a.a.

11 a.a.

338 a.a.

57 a.a.

126 a.a.

185 a.a.

Metals

_CA

PDB id:

8w8y

Name:

Membrane protein

Title:

Cryo-em structure of gamma-msh-mc3r-gs_nb35 complex

Structure:

Soluble cytochrome b562,melanocortin receptor 3,fusion protein. Chain: r. Synonym: cytochrome b-562,mc3-r. Engineered: yes. Gama-msh. Chain: l. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit

Source:

Escherichia coli, homo sapiens. Human. Organism_taxid: 562, 9606. Gene: cybc, mc3r. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Synthetic: yes. Homo sapiens. Organism_taxid: 9606.

Authors:

Q.Chen,J.Fu

Key ref:

F.Jingpeng and h.hongli Structure basis of ligand selectivity and signal transduction in human melanocortin-3 receptor. To be published, .

Date:

04-Sep-23 Release date: 19-Mar-25

Protein chain

P0ABE7  (C562_ECOLX) -  Soluble cytochrome b562 from Escherichia coli

Seq: 128 a.a.

Struc: 260 a.a.*

Protein chain

P41968  (MC3R_HUMAN) -  Melanocortin receptor 3 from Homo sapiens

Seq: 323 a.a.

Struc: 260 a.a.

Protein chain

No UniProt id for this chain

Struc: 11 a.a.

Protein chain

P54311  (GBB1_RAT) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Rattus norvegicus

Seq: 340 a.a.

Struc: 338 a.a.

Protein chain

P63212  (GBG2_BOVIN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Bos taurus

Seq: 71 a.a.

Struc: 57 a.a.

Protein chain

No UniProt id for this chain

Struc: 126 a.a.

Protein chain

P63092  (GNAS2_HUMAN) -  Guanine nucleotide-binding protein G(s) subunit alpha isoforms short from Homo sapiens

Seq: 394 a.a.

Struc: 185 a.a.*

* PDB and UniProt seqs differ at 145 residue positions (black crosses)