PDBsum entry 8w8q

Membrane protein

PDB id: 8w8q

Contents

Protein chains

287 a.a.

232 a.a.

339 a.a.

58 a.a.

128 a.a.

PDB id:

8w8q

Name:

Membrane protein

Title:

Cryo-em structure of the gpr101-gs complex

Structure:

Soluble cytochrome b562,probable g-protein coupled receptor 101. Chain: c. Synonym: cytochrome b-562. Engineered: yes. Guanine nucleotide-binding protein g(s) subunit alpha isoforms short. Chain: a. Synonym: adenylate cyclase-stimulating g alpha protein.

Source:

Escherichia coli, homo sapiens. Human. Organism_taxid: 562, 9606. Gene: cybc, gpr101. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Homo sapiens. Organism_taxid: 9606. Gene: gnas, gnas1, gsp.

Authors:

J.P.Sun,N.Gao,X.Yu,G.P.Wang,F.Yang,J.Y.Wang,Z.Yang,Y.Guan

Key ref:

Z.Yang et al. Structure of gpr101-Gs enables identification of liga with rejuvenating potential.. Nat chem biol, . PubMed id: 37945893

Date:

04-Sep-23 Release date: 03-Jan-24

Protein chain

P0ABE7  (C562_ECOLX) -  Soluble cytochrome b562 from Escherichia coli

Seq: 128 a.a.

Struc: 287 a.a.*

Protein chain

Q96P66  (GP101_HUMAN) -  Probable G-protein coupled receptor 101 from Homo sapiens

Seq: 508 a.a.

Struc: 287 a.a.

Protein chain

P63092  (GNAS2_HUMAN) -  Guanine nucleotide-binding protein G(s) subunit alpha isoforms short from Homo sapiens

Seq: 394 a.a.

Struc: 232 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 339 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 58 a.a.

Protein chain

No UniProt id for this chain

Struc: 128 a.a.

* PDB and UniProt seqs differ at 107 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????