PDBsum entry 8w8b

Membrane protein

PDB id: 8w8b

Contents

Protein chains

217 a.a.

328 a.a.

228 a.a.

45 a.a.

278 a.a.

Ligands

CLR ×5

PLM

UJL

PDB id:

8w8b

Name:

Membrane protein

Title:

Cryo-em structure of sep-363856 bounded serotonin 1a (5-ht1a) receptor-gi protein complex

Structure:

Guanine nucleotide-binding protein g(i) subunit alpha-1. Chain: a. Synonym: adenylate cyclase-inhibiting g alpha protein. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b. Synonym: transducin beta chain 1. Engineered: yes.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: gnai1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: gnb1. Gene: gng2. Escherichia coli, homo sapiens.

Authors:

H.Liu,Y.Zheng,Y.Wang,Y.Wang,X.He,P.Xu,S.Huang,Q.Yuan,X.Zhang,S.Wang, H.E.Xu,F.Xu

Key ref:

H.Liu et al. Recognition of methamphetamine and other amines by tr amine receptor taar1.. Nature, . PubMed id: 37935377

Date:

01-Sep-23 Release date: 22-Nov-23

Protein chain

P63096  (GNAI1_HUMAN) -  Guanine nucleotide-binding protein G(i) subunit alpha-1 from Homo sapiens

Seq: 354 a.a.

Struc: 217 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 328 a.a.

Protein chain

No UniProt id for this chain

Struc: 228 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 45 a.a.

Protein chain

P08908  (5HT1A_HUMAN) -  5-hydroxytryptamine receptor 1A from Homo sapiens

Seq: 422 a.a.

Struc: 278 a.a.*

Protein chain

P0ABE7  (C562_ECOLX) -  Soluble cytochrome b562 from Escherichia coli

Seq: 128 a.a.

Struc: 278 a.a.*

* PDB and UniProt seqs differ at 111 residue positions (black crosses)