PDBsum entry 8w88

Membrane protein

PDB id: 8w88

Contents

Protein chains

236 a.a.

338 a.a.

57 a.a.

127 a.a.

281 a.a.

Ligands

CLR ×3

UJL

PDB id:

8w88

Name:

Membrane protein

Title:

Cryo-em structure of the sep363856-bound taar1-gs complex

Structure:

Guanine nucleotide-binding protein g(s) subunit alpha isoforms short. Chain: a. Synonym: adenylate cyclase-stimulating g alpha protein. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b. Synonym: transducin beta chain 1.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: gnas, gnas1, gsp. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: gnb1. Gene: gng2. Lama glama.

Authors:

H.Liu,Y.Zheng,Y.Wang,Y.Wang,X.He,P.Xu,S.Huang,Q.Yuan,X.Zhang,S.Wang, H.E.Xu,F.Xu

Key ref:

H.Liu et al. Recognition of methamphetamine and other amines by tr amine receptor taar1.. Nature, . PubMed id: 37935377

Date:

01-Sep-23 Release date: 22-Nov-23

Protein chain

P63092  (GNAS2_HUMAN) -  Guanine nucleotide-binding protein G(s) subunit alpha isoforms short from Homo sapiens

Seq: 394 a.a.

Struc: 236 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 338 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 57 a.a.

Protein chain

No UniProt id for this chain

Struc: 127 a.a.

Protein chain

Q96RJ0  (TAAR1_HUMAN) -  Trace amine-associated receptor 1 from Homo sapiens

Seq: 339 a.a.

Struc: 281 a.a.

* PDB and UniProt seqs differ at 2 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????