PDBsum entry 8uwl

Membrane protein

PDB id: 8uwl

Contents

Protein chains

276 a.a.

227 a.a.

338 a.a.

53 a.a.

229 a.a.

Ligands

H8G

PDB id:

8uwl

Name:

Membrane protein

Title:

5-ht2ar bound to lisuride in complex with a mini-gq protein and an active-state stabilizing single-chain variable fragment (scfv16) obtained by cryo-electron microscopy (cryoem)

Structure:

5-hydroxytryptamine receptor 2a. Chain: a. Synonym: 5-ht-2,5-ht-2a,serotonin receptor 2a. Engineered: yes. G protein subunit q (gi2-mini-gq chimera). Chain: b. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: htr2a, htr2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: gnb1. Gene: gng2. Expression_system_taxid: 7108

Authors:

X.Barros-Alvarez,K.Kim,O.Panova,B.L.Roth,G.Skiniotis

Key ref:

J.Lyu et al. Alphafold2 structures guide prospective ligand discov. Science, . PubMed id: 38753765

Date:

06-Nov-23 Release date: 29-May-24

Protein chain

P28223  (5HT2A_HUMAN) -  5-hydroxytryptamine receptor 2A from Homo sapiens

Seq: 471 a.a.

Struc: 276 a.a.

Protein chain

No UniProt id for this chain

Struc: 227 a.a.

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 338 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 53 a.a.

Protein chain

No UniProt id for this chain

Struc: 229 a.a.