PDBsum entry 8utd

Membrane protein

PDB id: 8utd

Contents

Protein chains

292 a.a.

231 a.a.

221 a.a.

338 a.a.

56 a.a.

Ligands

XOT

PDB id:

8utd

Name:

Membrane protein

Title:

Cryoem structure of hca2-gi1 in complex with mk-1903

Structure:

Hydroxycarboxylic acid receptor 2. Chain: r. Engineered: yes. Mutation: yes. Scfv16. Chain: d. Engineered: yes. Guanine nucleotide-binding protein g(i) subunit alpha-1. Chain: a.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: hcar2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Lama glama. Organism_taxid: 9844. Gene: gnai1.

Authors:

B.E.Krumm,H.J.Kang,J.F.Diberto,N.J.Kapolka,R.H.Gumpper,R.H.J.Olsen, X.P.Huang,S.Zhang,J.F.Fay,B.L.Roth

Key ref:

H.J.Kang et al. (2024). Structure-Guided design of a peripherally restricted chemogenetic system.. Cell, 187, 7433. PubMed id: 39631393

Date:

30-Oct-23 Release date: 26-Feb-25

Protein chain

Q8TDS4  (HCAR2_HUMAN) -  Hydroxycarboxylic acid receptor 2 from Homo sapiens

Seq: 363 a.a.

Struc: 292 a.a.*

Protein chain

No UniProt id for this chain

Struc: 231 a.a.

Protein chain

P63096  (GNAI1_HUMAN) -  Guanine nucleotide-binding protein G(i) subunit alpha-1 from Homo sapiens

Seq: 354 a.a.

Struc: 221 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 338 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 56 a.a.

* PDB and UniProt seqs differ at 3 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????